Dermatology Made Easy is based on the most popular topics from DermNet NZ's vast array of material. The book combines the essential focus of the ‘Made Easy’ book series with the authority and knowledge base of DermNet NZ's unparalleled resources.
Author: Vanessa Ngan, Staff Writer, 2002.
Benzocaine is a widely used local and topical anaesthetic. It is used in pharmaceutical preparations and rarely cosmetics. Doctors and dentists use benzocaine preparations, especially on mucosal surfaces such as the mouth, to prepare or 'numb' a site for injection.
|Preparations containing benzocaine|
Benzocaine is a para-aminobenzoic acid (PABA) derivative and cross-reacts with other benzoic acid derived local anaesthetics (both topical and injectable forms). It also has the potential to cross-react with paraphenylenediamine found in permanent hair dyes, sulfonamides, sulfonylureas, PABA-based suncreens, and thiazide-related diuretics.
Benzocaine sensitivity produces classic allergic contact dermatitis reactions. Sometimes it may be seen as a flare or spread of an existing treated rash. Occasionally injection of PABA-derived local anaesthetics to benzocaine-allergic individuals may cause swelling of the oral mucosa at the site of the injection. Rarely, more severe reactions such as generalised urticaria or anaphylaxis may result.
Benzocaine allergy is diagnosed by performing special allergy tests, i.e. patch tests with 5% benzocaine in petrolatum.
Allergy to benzocaine may also mean you are allergic to other local anaesthetic agents.
|Cross-reacting local anaesthetics|
|Para-aminobenzoic acid based||Meta-aminobenzoic acid based||Benzoic acid based|
If you are diagnosed with benzocaine allergy then avoid exposure to benzocaine containing products. Once the dermatitis appears on the skin, treatment is as for any acute dermatitis/eczema, i.e. topical corticosteroids, emollients, treatment of any secondary bacterial infection (Staphylococcus aureus), etc.
Read product labels and avoid products that contain benzocaine or any of its alternative names. Avoid related substances that you may also be allergic to. This includes PABA, meta-aminobenzoic acid or benzoic acid local anaesthetics (both topical and injectable forms), paraphenylenediamine found in permanent hair dyes, sulfonamides, sulfonylureas, PABA-based suncreens, and thiazide-related diuretics.
Any products that are labelled 'anaesthetic' or 'caine' should be suspected of containing benzocaine or a related compound. These should be avoided. Ask your pharmacist for advice and a suitable alternative.
Alert your doctor and dentist to the fact that you have an allergy to benzocaine. Your dermatologist may have further specific advice, particularly if you are highly sensitive.
Benzocaine is also known by several other names. These include:
The chemical formula of benzocaine is C9H11NO2.
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